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Objective To observe the effect of the therapy of tonifying the kidney on plasma NO and ET in dog with myocardial ischemia. Methods 20 dogs of myocarclial ischemia were divided into the model group control group, isosorbide mononitrate group and the therapy of tonifying the kidney group by random. The NO and ET of serum were measured before and after treatment. Results The level of NO was higher and the level of ET was lower than that of the isosorbide mononitrate group. There was significant difference between the control group and the therapy of tonifying the kidney group (P
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Objective To observe the effect of Guanxin Ⅱ Hao on plasma NO and NOS in dog with myocardial ischemia. Methods 20 dogs of myocardial ischemia were divided into the control group, isosorbidi mononitratis group and the Guanxin Ⅱ Hao group by random. The NO and NOS of serum were measured, before and after treatment. Results In the control group, the level of NO and NOS were higher than that of the isosorbide mononitrate group. There was significant difference between the control group and the Guanxin II Hao groups (P
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Objective To observe the influences on NO, NOS, ET of the Therapy of Tonifying the Kidney in patients with angina pectoris. Methods 50 patients with angina pectoris were treated by Chinese medicine of tonifying the kindey and the NO, NOS, ET, symptoms, ECG (ischemic ST-T changes), holter ECG, blood viscosity and blood fat were recorded. Results Obvious rise of NO, NOS and drop of ET. The improving of NO(?mol/L) from 46.42?7.94 to 70.16?12.94, NOS(u/mL) from 1.62?0.22 to 2.36?0.30, ET(pg/mL) from 64.46?15.12 to 41.42?8.76, the total efficacy of Chinese medicine of tomifying the kidney to improving of angina pectoris amounted to 92%, to improving of ECG amounted to 68%, the improving time (minutes) of holter ECG from 104.70?12.25 to 24.26?3.41. The rise of NO, NOS, the drop of ET and the therapeutic efficacy of Chinese medicine of tonifying the kidney are better than isosorbidi mononitratis with significant difference (P
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【Objective】 To investigate the synergistic action of therapy of strengthening Qi,warming yang,activating blood to promote diuresis on routine western medicine for congestive heart failure(CHF) and to observe its effect on neuroendocrine factors.【Methods】Seventy CHF patients with cardiac function of grade Ⅱ～Ⅳ which were classified into Qi deficiency and blood stasis complicated with fluid retention,were randomized into groups A(n=42) and B(n=28).Group B received routine treatment with digoxin,diuretics,angiotensin converting enzyme inhibitors and ? receptor antagonists.Group A additionally received oral use of decoction of herbal medicines of Radix Astragali,Herba Epimedii,Herba Leonuri,Rhizoma Alismatis,etc.,which has the actions of strengthening Qi,warming yang,activating blood to promote diuresis.Four weeks constituted one treatment course.The therapeutic effect as well as the changes of cardiac function and neuroendocrine factors before and after treatment was observed.【Results】In group A,24 were markedly effective,16 effective,2 ineffective and the total effective rate was 95.24%;in group B,19 were markedly effective,4 effective,5 ineffective and the total effective rate was 82.14%.The therapeutic effect in group A was superior to group B(P